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David M Bedwell Selected Research

Iduronidase (alpha-L-Iduronidase)

3/2014Long-term nonsense suppression therapy moderates MPS I-H disease progression.
1/2012The designer aminoglycoside NB84 significantly reduces glycosaminoglycan accumulation associated with MPS I-H in the Idua-W392X mouse.

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David M Bedwell Research Topics

Disease

9Inborn Genetic Diseases (Disease, Hereditary)
06/2020 - 06/2002
8Cystic Fibrosis (Mucoviscidosis)
01/2021 - 09/2002
3Mucopolysaccharidosis I (Hurler Syndrome)
03/2014 - 06/2002
3Lysosomal Storage Diseases (Lysosomal Storage Disease)
03/2014 - 06/2002
2Neurofibromatosis 1 (Neurofibromatosis Type I)
01/2022 - 06/2020
2Neoplasms (Cancer)
06/2020 - 06/2002
1Starvation
05/2015
1Ototoxicity
04/2014
1Disease Progression
03/2014
1Human Influenza (Influenza)
09/2013
1Infections
09/2013
1Benign Familial Pemphigus (Hailey Hailey Disease)
01/2006

Drug/Important Bio-Agent (IBA)

10Nonsense Codon (Nonsense Mutation)IBA
11/2016 - 06/2002
5Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
11/2016 - 09/2002
3AminoglycosidesIBA
11/2011 - 06/2002
2Neurofibromin 1 (Neurofibromin)IBA
01/2022 - 06/2020
2Proteins (Proteins, Gene)FDA Link
01/2022 - 05/2015
2Terminator Codon (Termination Codon)IBA
01/2021 - 02/2008
2Gentamicins (Gentamicin)FDA LinkGeneric
04/2014 - 03/2009
2Iduronidase (alpha-L-Iduronidase)IBA
03/2014 - 01/2012
1Deubiquitinating EnzymesIBA
05/2015
1NitrogenIBA
05/2015
1RNA (Ribonucleic Acid)IBA
05/2015
1EndonucleasesIBA
01/2014
1Interleukin-6 (Interleukin 6)IBA
09/2013
1AnionsIBA
09/2013
1Clodronic Acid (Clodronate)IBA
09/2013
1Liposomes (Liposome)IBA
09/2013
1GlycosaminoglycansIBA
01/2012
1Aspartic Acid (Aspartate)FDA Link
03/2009
1atalurenIBA
02/2008

Therapy/Procedure

7Therapeutics
06/2020 - 06/2002